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Edward P. O'Brien
Edward P. O'Brien
Professor, Pennsylvania State University, University Park
Verified email at psu.edu - Homepage
Title
Cited by
Cited by
Year
Interactions between hydrophobic and ionic solutes in aqueous guanidinium chloride and urea solutions: lessons for protein denaturation mechanism
EP O'Brien, RI Dima, B Brooks, D Thirumalai
Journal of the American Chemical Society 129 (23), 7346-7353, 2007
4052007
Cotranslational protein folding inside the ribosome exit tunnel
OB Nilsson, R Hedman, J Marino, S Wickles, L Bischoff, M Johansson, ...
Cell reports 12 (10), 1533-1540, 2015
2742015
Theoretical perspectives on protein folding
D Thirumalai, EP O'Brien, G Morrison, C Hyeon
Annual review of biophysics 39, 159-183, 2010
2042010
Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model
EP O'Brien, G Ziv, G Haran, BR Brooks, D Thirumalai
Proceedings of the National Academy of Sciences 105 (36), 13403-13408, 2008
1902008
Profiling Ssb-nascent chain interactions reveals principles of Hsp70-assisted folding
K Döring, N Ahmed, T Riemer, HG Suresh, Y Vainshtein, M Habich, ...
Cell 170 (2), 298-311. e20, 2017
1662017
Does SARS-CoV-2 bind to human ACE2 more strongly than does SARS-CoV?
HL Nguyen, PD Lan, NQ Thai, DA Nissley, EP O’Brien, MS Li
The Journal of Physical Chemistry B 124 (34), 7336-7347, 2020
1282020
Effects of pH on proteins: predictions for ensemble and single-molecule pulling experiments
EP O’Brien, BR Brooks, D Thirumalai
Journal of the American Chemical Society 134 (2), 979-987, 2012
1132012
Understanding the influence of codon translation rates on cotranslational protein folding
EP O’Brien, P Ciryam, M Vendruscolo, CM Dobson
Accounts of chemical research 47 (5), 1536-1544, 2014
1072014
Prediction of variable translation rate effects on cotranslational protein folding
EP O'brien, M Vendruscolo, CM Dobson
Nature communications 3 (1), 868, 2012
1062012
How accurate are polymer models in the analysis of Förster resonance energy transfer experiments on proteins?
EP O’Brien, G Morrison, BR Brooks, D Thirumalai
The Journal of Chemical Physics 130 (12), 2009
1052009
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome
P Ciryam, RI Morimoto, M Vendruscolo, CM Dobson, EP O’Brien
Proceedings of the National Academy of Sciences 110 (2), E132-E140, 2013
1032013
Thermodynamic perspective on the dock− lock growth mechanism of amyloid fibrils
EP O’Brien, Y Okamoto, JE Straub, BR Brooks, D Thirumalai
The Journal of Physical Chemistry B 113 (43), 14421-14430, 2009
1032009
New scenarios of protein folding can occur on the ribosome
EP O’Brien, J Christodoulou, M Vendruscolo, CM Dobson
Journal of the American Chemical Society 133 (3), 513-526, 2011
992011
Transient tertiary structure formation within the ribosome exit port
EP O’Brien, STD Hsu, J Christodoulou, M Vendruscolo, CM Dobson
Journal of the American Chemical Society 132 (47), 16928-16937, 2010
902010
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions
EP O’Brien, J Christodoulou, M Vendruscolo, CM Dobson
Journal of the American Chemical Society 134 (26), 10920-10932, 2012
862012
Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates
EP O’Brien, M Vendruscolo, CM Dobson
Nature communications 5 (1), 2988, 2014
842014
Collapse kinetics and chevron plots from simulations of denaturant-dependent folding of globular proteins
Z Liu, G Reddy, EP O’Brien, D Thirumalai
Proceedings of the National Academy of Sciences 108 (19), 7787-7792, 2011
752011
Effect of finite size on cooperativity and rates of protein folding
M Kouza, MS Li, EP O'Brien, CK Hu, D Thirumalai
The Journal of Physical Chemistry A 110 (2), 671-676, 2006
752006
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data
AK Sharma, P Sormanni, N Ahmed, P Ciryam, UA Friedrich, G Kramer, ...
PLoS computational biology 15 (5), e1007070, 2019
582019
Influence of nanoparticle size and shape on oligomer formation of an amyloidogenic peptide
EP O’Brien, JE Straub, BR Brooks, D Thirumalai
The journal of physical chemistry letters 2 (10), 1171-1177, 2011
582011
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