David Brealey
David Brealey
Consultant Intensive Care Medicine, University College Hospital
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Cited by
Cited by
Association between mitochondrial dysfunction and severity and outcome of septic shock
D Brealey, M Brand, I Hargreaves, S Heales, J Land, R Smolenski, ...
The Lancet 360 (9328), 219-223, 2002
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
RM Venn, CJ Bradshaw, R Spencer, D Brealey, E Caudwell, C Naughton, ...
Anaesthesia 54 (12), 1136-1142, 1999
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure
D Brealey, S Karyampudi, TS Jacques, M Novelli, R Stidwill, V Taylor, ...
American Journal of Physiology-Regulatory, Integrative and Comparative …, 2004
Levosimendan for the prevention of acute organ dysfunction in sepsis
AC Gordon, GD Perkins, M Singer, DF McAuley, RML Orme, ...
New England Journal of Medicine 375 (17), 1638-1648, 2016
Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial
T Richards, RR Baikady, B Clevenger, A Butcher, S Abeysiri, M Chau, ...
The Lancet 396 (10259), 1353-1361, 2020
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study
RK Gupta, EM Harrison, A Ho, AB Docherty, SR Knight, M van Smeden, ...
The Lancet Respiratory Medicine 9 (4), 349-359, 2021
Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study
P Sinha, CS Calfee, S Cherian, D Brealey, S Cutler, C King, C Killick, ...
The Lancet Respiratory Medicine 8 (12), 1209-1218, 2020
Rapid diagnosis of infection in the critically ill, a multicenter study of molecular detection in bloodstream infections, pneumonia, and sterile site infections
JL Vincent, D Brealey, N Libert, NE Abidi, M O’Dwyer, K Zacharowski, ...
Critical care medicine 43 (11), 2283-2291, 2015
Mitochondrial dysfunction in sepsis
D Brealey, M Singer
Current infectious disease reports 5 (5), 365-371, 2003
Mitochondrial dysfunction in sepsis
M Singer, D Brealey
Biochemical Society Symposia 66, 149-166, 1999
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the …
CI Bloom, TM Drake, AB Docherty, BJ Lipworth, SL Johnston, ...
The Lancet Respiratory Medicine 9 (7), 699-711, 2021
Effect of human recombinant alkaline phosphatase on 7-day creatinine clearance in patients with sepsis-associated acute kidney injury: a randomized clinical trial
P Pickkers, RL Mehta, PT Murray, M Joannidis, BA Molitoris, JA Kellum, ...
Jama 320 (19), 1998-2009, 2018
Effect of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal vs standard care ventilation on 90-day mortality in patients with acute hypoxemic …
JJ McNamee, MA Gillies, NA Barrett, GD Perkins, W Tunnicliffe, D Young, ...
Jama 326 (11), 1013-1023, 2021
Hyperglycemia in critical illness: a review
D Brealey, M Singer
Journal of diabetes science and technology 3 (6), 1250-1260, 2009
Effect of intravenous interferon β-1a on death and days free from mechanical ventilation among patients with moderate to severe acute respiratory distress syndrome: a …
VM Ranieri, V Pettilä, MK Karvonen, J Jalkanen, P Nightingale, D Brealey, ...
Jama 323 (8), 725-733, 2020
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind …
T Welte, RP Dellinger, H Ebelt, M Ferrer, SM Opal, M Singer, JL Vincent, ...
Intensive care medicine 44, 438-448, 2018
Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components
DA Svistunenko, N Davies, D Brealey, M Singer, CE Cooper
Biochimica Et Biophysica Acta (BBA)-Bioenergetics 1757 (4), 262-272, 2006
Evidence for chemokine synergy during neutrophil migration in ARDS
AE Williams, RJ José, PF Mercer, D Brealey, D Parekh, DR Thickett, ...
Thorax 72 (1), 66-73, 2017
Effect of intermittent or continuous feed on muscle wasting in critical illness: a phase 2 clinical trial
AS McNelly, DE Bear, BA Connolly, G Arbane, L Allum, A Tarbhai, ...
Chest 158 (1), 183-194, 2020
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